Villar-del-Moral et al reported prognostic factors for a patient with parathyroid carcinoma. This can help to identify a patient who may benefit from more aggressive management. The authors are from multiple institutions in Spain.
Patient selection: parathyroid carcinoma
Factors associated with recurrence:
(1) intraoperative tumor rupture (hazard ratio 6.2)
(2) mitotic activity in tumor cells (hazard ratio 4.8)
(3) Schulte stage III (T4 N0M0 or TanyN1M0; hazard ratio 5.2)
where:
• Stage IV would also impact recurrence but disease-specific survival might be more important.
Factors associated with poor disease-specific survival:
(1) intraoperative tumor rupture (hazard ratio 58.7)
(2) distant recurrence (hazard ratio 38.7)
Prognosis is greatly influence by the surgeon's performance (and probably adequacy of the original excision).
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