The Italian Guillain-Barre Study Group identified a number of prognostic factors that may affect the outcome for a patient with Guillain-Barre syndrome. These can help identify patients who may require more aggressive management. The authors are from multiple university medical centers throughout Italy.


Factors associated with a poor chance for recovery:

(1) age > 54 years

(2) antecedent gastroenteritis

(3) disability (chairbound or bedbound, respiratory insufficiency)

(4) electrodiagnostic features of axonopathy (pure or mixed)

(5) delayed nadir (>= 3 weeks)

(6) duration of active disease >= 3 weeks



• The primary electrodiagnostic feature of axonopathy was markedly reduced or absent compound muscle action potential in 2 or more motor nerves (Table 1, page 2055)


Interestingly the outcome at 1 year for different modalities was similar (Figure 3, page 2058), but plasmapheresis resulted in faster improvement during the first 3 months.


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