Tefferi et al reported prognostic factors for patients with blast phase myeloproliferativeneoplasma (MPN-BP). These can help in the management of a patient in transition to acute leukemia. The authors are from multiple institutions in the United States and Italy.
Parameters from multivariate analysis:
(1) age in years
(2) transfusion dependence
(3) platelet count
(4) karyotype
Parameter
Finding
Points
age in years
<= 65 years
0
> 65 years
1
transfusion dependent
no
0
yes
1
platelet count
>= 100 * 10^9/L
0
< 100 * 10^9/L
1
karyotype
not high risk
0
high risk (unfavorable)
1
number of factors =
= SUM(points for all of the parameters)
Interpretation:
• minimum number of factors: 0
• maximum number of factors: 4
• The risk of leukemia transformation with worse overall survival increases with the number of prognostic factors present.
To read more or access our algorithms and calculators, please log in or register.
