Suzuki et al evaluated patients with surgically resected non-small cell lung carcinoma based on prognostic features selected for each tumor stage. This can help better individualize the survival prediction. The authors are from the National Cancer Hospital in Tokyo and the National Cancer Hospital in Chiba, Japan.
Patient selection: adenocarcinoma, squamous cell carcinoma, other (large cell undifferentiated carcinoma, etc.)
|
Stage |
Favorable Prognostic Factors |
|
I |
N0 or N1; no vascular invasion, completely resected |
|
II, III or IV |
N0 or N1; not an adenocarcinoma; small tumor size; completely resected |
from Table 2 and Table 5
Patients with Stage IV disease had a dismal prognosis only a small percentage surviving more than 1 year.
|
Stage |
Finding 1 |
Finding 2 |
Probability of 5 Year Survival |
|
I |
N0 or N1 |
no vascular invasion |
92% |
|
I |
N2 |
no vascular invasion |
72% |
|
I |
N0 or N1 |
vascular invasion |
72% |
|
I |
N2 |
vascular invasion |
21% |
|
II |
not adenocarcinoma |
<= 3 cm |
88% |
|
II |
adenocarcinoma |
<= 3 cm |
76% |
|
II |
not adenocarcinoma |
> 3 cm |
76% |
|
II |
adenocarcinoma |
> 3 cm |
25% |
|
IIIA |
<= 3 cm |
|
48% |
|
IIIA |
> 3 cm |
|
22% |
|
IIIB |
N0 or N1 |
complete resect |
72% |
|
IIIB |
N0 or N1 |
incomplete |
18% |
|
IIIB |
N2 or N3 |
complete resect |
18% |
|
IIIB |
N2 or N3 |
incomplete |
10% |
where:
• Complete resection indicates a negative surgical margin and the highest mediastinal lymph node negative for tumor.
• Incomplete resection indicates a positive surgical margin and/or the highest mediastinal lymph node positive for tumor.
• A Stage IIIB tumor with N0 or N1 has to be a T4 lesion.
Specialty: Hematology Oncology, Surgery, general, Pulmonology
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