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Prognostic Factors of Shoup et al for a Patient with Metastatic Differentiated Thyroid Carcinoma

Description

Shoup et al identified factors affecting prognosis in a patient with metastatic differentiated thyroid carcinoma. This can help identify patients who may benefit from more aggressive management or novel therapies. The authors are from the Memorial Sloan-Kettering Cancer Center in New York City.


 

Patient selection: metastatic differentiated carcinoma - papillary (most), follicular or Hurthle cell

 

Exclusions: medullary carcinoma, anaplastic thyroid carcinoma, malignant lymphoma, coexisting advanced solid organ malignancy other than thyroid

 

Prognostic factors associated with a poor prognosis identified on multivariate analysis:

(1) age >= 45 years

(2) symptomatic distant metastases (bone pain, pathologic fracture, dyspnea, hemoptysis)

(3) metastatic disease other than lung only or bone only (more than 1 site, another site)

(4) no therapy with radioactive iodine

 

A patient with 1 of these findings has a 10 year disease free survival from 11-16%.

 


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