Shi et al evaluated patients with antisynthetase autoantibodies. They identified risk factors associated with a worse prognosis. The authors are from Peking University and China-Japan Friendship Hospital in Beijing.
Patient selection: anti-synthetase autoantibodies
Poor prognostic factors:
(1) rapidly-progressive interstitial lung disease (RP-ILD). This is an interstitial lung disease with worsening of radiological interstitial changes with progressive dyspnea and hypoxemia within 3 month after the onset of respiratory symptoms.
(2) malignancy (breast, stomach, cervix, etc)
(3) elevated serum ferritin (hyperferritinemia, above the upper limit of normal reference range)
Rapidly-progressive ILD was more common in patients with:
(1) anti-PL7
(2) anti-Ro-52
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