Savage et al reported prognostic factors for patients with an ALK-negative anaplastic large-cell lymphoma (ALCL) These can help to identify a patient who may benefit from more aggressive management. The authors are from institutions around the world participating in the International Peripheral T-Cell Lymphoma Project.
Outcomes: overall survival and failure-free survival (FFS)
Parameters:
(1) performance score
(2) clinical stage
(3) serum LDH
Parameter
Finding
Points
performance scale
0 to 2
0
3 or 4
1
clinical stage
I or II
0
III
1
IV
2
serum LDH
normal
0
elevated
1
total number of adverse prognostic factors =
= SUM(points for all 3 prognostic factors)
Interpretation:
• minimum number of adverse prognostic factors: 0
• maximum number of adverse prognostic factors: 3
• The outcome is worse as the number of adverse prognostic factors increase.
• The prognosis for an ALK-negative ALCL is worse than for a patient with an ALK+ ALCL.
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