Pichler et al identified a number of factors impacting survival in a patient with clear cell renal cell carcinoma (RCC). These can help to identify a patient who may benefit from more aggressive management. The authors are from the Medical University of Graz in Austria.
Patient selection: clear cell RCC
Outcomes: metastasis-free survival (MFS) and overall survival (OAS)
Parameters:
(1) age
(2) gender
(3) pT stage
(4) tumor histologic grade
(5) tumor necrosis
(6) histologic sarcomatoid component
(7) vascular invasion
|
Parameter |
Finding |
HR MFS |
HR OAS |
|
age |
<= 65 years of age |
NA |
1 |
|
|
> 65 years |
NA |
1.8 |
|
gender |
female |
1 |
1 |
|
|
male |
1.3 |
1.3 |
|
pT stage |
pT1 or pT2 |
1 |
1 |
|
|
pT3 or pT4 |
2.2 |
1.5 |
|
histologic grade |
G1 or G2 |
1 |
1 |
|
|
G3 or G4 |
1.8 |
1.8 |
|
tumor necrosis |
absent |
1 |
1 |
|
|
present |
2.3 |
1.5 |
|
sarcomatoid component |
absent |
1 |
1 |
|
|
present |
1.9 |
1.7 |
|
vascular nvasion |
absent |
1 |
1 |
|
|
present |
2.3 |
1.9 |
cumulative product of hazard ratios =
= PRODUCT(all of applicable parameters)
Interpretation:
• minimum cumulative hazard ratio: 1
• maximum cumulative hazard ratio for a worse metastasis-free survival: 51.7
• maximum cumulative hazard ratio for a worse overall survival: 30.6
Specialty: Hematology Oncology, Surgery, general, Nephrology
ICD-10: ,
