Parry-Jones et al identified prognostic factors associated with survival in patients with a splenic lymphoma featuring villous lymphocytes. This can help identify patients who may benefit from more aggressive management. The authors are from the Royal Marsden NHS Trust and Institute of Cancer Research in England.


Prognostic factors:

(1) age > 70 years

(2) anemia (hemoglobin < 11 g/dL)

(3) thrombocytopenia (platelet count < 100,000 per µL)

(4) lymphocytosis

(5) type of therapy

(6) transformation to high-grade lymphoma (with bulky lymphadenopathy and circulating blasts)


Significant factors related to lymphoma-specific survival:

(1) anemia

(2) lymphocytosis > 16,000 per µL


The presence of significant comorbid conditions may contributes to shortened survival.


The disease tends to follow an indolent course, and some patients do not require therapy. If therapy is required, then survival after splenectomy is significantly superior to that after chemotherapy.


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