Park et al evaluated the prognosis for women with breast cancer metastatic to the brain. These can help to identify a woman who may benefit from more aggressive or a novel therapy. The authors are from Sungkyunkwan University in Seoul, South Korea.
Patient selection: breast cancer metastatic to brain with ECOG performance status 0 to 2
Parameters:
(1) ECOG performance status
(2) HER2-neu status
(3) additional systemic chemotherapy
Parameter
Finding
Points
ECOG performance
0 or 1
0
2
1
HER2-neu
negative
0
positive
1
additional systemic therapy
yes
0
no
1
total number of poor prognostic factors =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse the prognosis.
Score
Prognosis
Median Overall Survival
0
fair
49 months
1
suboptimal
11 months
2
poor
4 months
3
very poor
2 months
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