Ou et al evaluated risk factors affecting survival in patients with Stage I non-small cell lung cancer (NSCLC). These can help identify patients who may benefit from more aggressive or novel therapies. The authors are from the Chao Family Comprehensive Cancer Center in Orange, California, and the University of California in Irvine.
|
TNM Designation |
Stage |
|
T1N0M0 |
IA |
|
T2N0M0 |
IB |
Parameters:
(1) age at diagnosis
(2) gender
(3) socioeconomic status
(4) therapy
(5) histologic grade
|
Parameter |
Finding |
Points |
|
age of the patient at diagnosis |
younger |
0 |
|
|
older |
1 |
|
gender |
female |
0 |
|
|
male |
1 |
|
socioeconomic status |
poor |
1 |
|
|
middle to upper class |
0 |
|
therapy |
surgery included |
0 |
|
|
nonsurgical |
1 |
|
histologic grade |
well or moderately differentiated |
0 |
|
|
poorly differentiated |
1 |
where:
• Age is a continuous variable. The most common age interval was 70 to 74 years. For the implementation an age >= 75 will be used to define older age.
total number of risk factors affecting survival =
= SUM(points for all 5 parameters)
Additional factors for a patient with Stage IB disease:
(1) tumor size >= 4 cm
(2) location in right middle, right lower or left lower lobe
Factors associated with decreased mortality:
(1) Asian ancestry
(2) broncho-alveolar carcinoma
Interpretation:
• minimum number of primary risk factors: 0
• maximum number of primary risk factors: 5
• The more risk factors that are present the worse the survival.
Specialty: Hematology Oncology, Surgery, general, Pulmonology
ICD-10: ,
