Naito et al identified prognostic factors for a patient with metastatic renal cell carcinoma who has undergone metastasectomy. These can help to identify a patient who may benefit from more aggressive or a novel therapy. The authors are from multiple hospitals in Japan.
Patient selection: metastatic renal cell carcinoma following resection of metastases
Parameters:
(1) highest histologic grade using the Japanese classification (Grades 1 to 3)
(2) serum C-reactive protein (CRP) in mg/dL
(3) brain metastases
(4) cancer status after metastasectomy
|
Parameter |
Finding |
Points |
|
highest histologic grade |
Grade 1 or 2 |
0 |
|
|
Grade 3 |
1 |
|
serum CRP |
<= 1 mg/dL |
0 |
|
|
> 1 mg/dL |
1 |
|
brain metastases |
no |
0 |
|
|
yes |
1 |
|
metastasectomy |
complete removal (including primary tumor) |
0 |
|
|
incomplete (residual tumor) |
1 |
total number of poor prognostic factors =
= SUM(points for all 4 parameters)
Interpretation:
• minimum number of poor prognostic factors: 0
• maximum number of poor prognostic factors: 4
• A patient with 3 or 4 poor prognostic factors had a poor prognosis.
|
Total Score |
Median Survival |
|
0 |
118 months |
|
1 |
88 months |
|
2 |
42 months |
|
3 |
11 months |
|
4 |
7 months |
Specialty: Hematology Oncology, Surgery, general
ICD-10: ,
