Mudireddy et al evaluated patients with essential thrombocythemia for factors affecting survival. These can help to identify a patient who may benefit from more aggressive management. The authors are from the Mayo Clinic in Rochester.
Patient selection: essential thrombocythemia
Outcome: mortality
Parameters from multivariate analysis:
(1) age in years
(2) gender
(3) serum LDH in IU/L
Parameter
Finding
Points
age in years
< 60 years
0
>= 60 years
1
gender
female
0
male
1
serum LDH
normal
0
elevated
1
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The presence of these 3 risk factors was associated with worse survival.
• Mild bone marrow reticulin fibrosis had limited use in predicting survival.
The presence of a leukocyte count >= 15,000 per µL was associated with worse survival in the univariate analysis but not the multivariate analysis, with serum LDH being a surrogate marker.
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