Mollet et al evaluated patients with a lung carcinoma that metastasizes to the skin. These patients are usually incurable and have a poor prognosis. The authors are from the University of Oklahoma.
Features of the lung cancers and skin metastases:
(1) Metastases may appear before or at the same time as the lung primary.
(2) Most tumors are high grade.
(3) TTF-1 is a helpful immunostain that can support the diagnosis of a lung primary.
Factors associated with a poor prognosis:
(1) multiple cutaneous metastases
(2) other distant metastases
(3) unresectable lung carcinoma
(4) small cell undifferentiated neuroendocrine carcinoma
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