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Prognostic Factors of Mekhail et al for Previously Untreated Metastatic Renal Cell Carcinoma

Description

Mekhail et al evaluated patients with metastatic renal cell carcinoma without previous systemic therapy. The study was based on the prognostic model of Motzer et al. The authors are from the Cleveland Clinic.


Patient selection: metastatic renal cell carcinoma without previous systemic therapy

 

Parameters:

(1) time from diagnosis to study entry in months

(2) hemoglobin in g/dL

(3) serum LDH in U/L

(4) corrected serum calcium in mg/dL

(5) history of prior radiotherapy

(6) number of sites with metastases (liver, lung, retroperitoneal lymph nodes)

 

corrected calcium =

= (measured calcium) - (0.707 * ((albumin) - 3.4))

 

Parameter

Finding

Points

time from diagnosis

< 12 months

1

 

>= 12 months

0

hemoglobin

less than lower limit of reference range (LLN)

1

 

above LLN

0

serum LDH

> 1.5 times upper limit of reference range (ULN)

1

 

< 1.5 times ULN

0

corrected serum calcium

> 10 mg/dL

1

 

<= 10 mg/dL

0

history of prior radiotherapy

no

0

 

yes

1

number of metastatic sites

0 or 1

0

 

2 or 3

1

 

score =

= SUM(points for all 6 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 6

 

Score

Prognostic Group

0 or 1

favorable

2

intermediate

3 to 6

poor

 


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