Mauro et al identified prognostic factors for patients with the onset of chronic lymphocytic leukemia (CLL) at an age <= 55 years. These can help to identify a patient who may benefit from more aggressive or novel management. The authors are from University "La Sapienza" of Rome and University of Turin.
Patient selection: CLL with onset <= 55 years of age
Parameters:
(1) presence or absence of active disease within 12 months from diagnosis (see 28.02.07)
(2) lymphocyte doubling time (LDT) in months (Montserrat et al)
Active Disease within 12 Months
Lymphocyte Doubling Time (LDT)
10-Year Survival Rate
present
NA
8%
absent
<= 12 months
42%
absent
> 12 months
60%
see page 449 and Figure 1 page 451
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