Li et al identified prognostic factors for a Chinese patient with chronic lymphocytic leukemia (CLL).

Patient selection: CLL


Factors associated with worse prognosis:

(1) unmutated IGHV status

(2) advanced Binet clinical stage (Stage C)

(3) del(17p13) or del(11q23)

(4) high expression of ZAP-70 (>= 20%)

(5) high expression of CD38 (>= 30%)



17p53 is associated with p53

11q23 is associated with ATM


number of prognostic factors =

= SUM(prognostic factors present)



minimum number: 0

maximum number: 5

The prognosis is worse with the number of factors present.

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