Lefebvre et al identified factors associated a worse survival in a patient with hypereosinophilia. These can help to identify a patient who may benefit from more aggressive management.
Patient selection: hypereosinophilia
Outcome: early mortality
Factors associated with a worse prognosis:
(1) male gender
(2) cardiac disease (heart failure, endomyocardial fibrosis, valve disease, other)
(3) myeloproliferative disorder
(4) eosinophilia refractory to corticosteroids
(5) high absolute eosinophil count
where:
• Other hematopoietic or solid malignancies associated with hypereosinophilia are also probably associated with a worse survival.
• The cut-off for the absolute eosinophil count was arbitrarily set to 10,000 per µL in the implementation.
The risk for poor survival increases with the number of risk factors present. Cardiac disease and an underlying malignancy are probably the most significant by themselves.
