Lee et al identified prognostic factors for a patient with myelodysplasia who is receiving an allogeneic hematopoietic cell transplantation. The authors are from the University of Ulsan and Asan Medical Center in Seoul, Korea.
Patient selection: myelodysplastic syndrome
Outcome: overall survival/mortality
Parameters:
(1) Karnofsky performance score (KPS)
(2) pre-transplant comorbidity based on the HCT-CI of Sorror et al
(3) International Prognostic Scoring System (IPSS) risk group
Parameter
Finding
Hazard Ratio
KPS
>= 90
1
<= 80
3.5
comorbidity
absent
1
present
3.7
IPSS
low or intermediate-1
1
intermediate-2 or high
4.3
where:
• The hazard ratio for KPS is derived from referencing hazard using >= 90 rather than <= 80 (in Table 4 shown HR for >= 90 as 0.282 vs 1 for <= 80.
