Prognostic Factors of Leavey et al for a Patient with Ewing Sarcoma at First Recurrence Following Multimodality Therapy

 

Patient selection: patient with a first recurrence of Ewing sarcoma after multimodality therapy

 

Factors associated with a worse survival from multivariate analysis:

(1) serum LDH elevated (> 250 IU/L) at initial diagnosis

(2) interval between therapy and first recurrence < 24 months

(3) first recurrence at initial sites plus a distant site not previously involved (according to definition of distant given in the footnotes to Tables I and II)

 

where:

• The cutoff for initial LDH would be affected by the analytical method.

 

Additional factors associated with worse survival:

(1) presence of metastases at initial diagnosis

(2) female gender