Lambert et al identified prognostic factors for a patient with treated Cushing's disease. These can help to identify a patient who may benefit from more aggressive management. The authors are from Mount Sinai School of Medicine in New York City.


Patient selection: treated Cushing's disease


Risk factors for cardiovascular disease:

(1) male gender

(2) older age at diagnosis

(3) diabetes

(4) depression


Risk factors for death:

(1) duration of excess glucocorticoid exposure (length of time from symptom onset to postoperative remission)

(2) older age at diagnosis

(3) preoperative ACTH concentration

(4) depression (if remission achieved)


Early diagnosis and treatment can significantly improve long-term outcomes.


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