Kurosawa et al identified factors impacting the survival of a patient with acute myeloid leukemia (AML) after the first relapse. The authors are from multiple cancer hospitals and universities in Japan including the National Cancer Center Hospital in Tokyo and the University of Tokyo.
Factors associate with a worse survival in multivariate analysis:
(1) failure to achieve a second complete remission (odds ratio 3.2)
(2) failure to perform a salvage allogeneic hematopoietic cell transplant (HCT, odds ratio 2.6)
(3) interval between first complete remission and relapse less than 12 months (odds ratio 1.8)
Additional factors associated with a worse survival:
(4) unfavorable cytogenetics (odds ratio 1.3)
(5) 2 courses of chemotherapy required to induce the first remission (odds ratio 1.2)
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