Kristensen et al identified histologic risk factors for prognosis in squamous cell carcinoma of the cervix. This can help identify patients with aggressive tumors requiring more aggressive management. The authors are from the Norwegian Radium Hospital in Oslo.
Parameters:
(1) clinical tumor size in cm
(2) histologic depth of invasion in mm
(3) histologic score at the invading edge of the tumor (see previous section)
|
Tumor Size |
Depth of Invasion |
Histologic Grade |
Risk Group |
|
< 2 cm |
<= 10 mm |
<= 8 |
minimal |
|
< 2 cm |
> 10 mm |
<= 8 |
minimal |
|
>= 2 cm |
<= 10 mm |
<= 8 |
minimal |
|
>= 2 cm |
> 10 mm |
<= 8 |
low |
|
< 2 cm |
<= 10 mm |
> 8 |
low |
|
< 2 cm |
> 10 mm |
> 8 |
low |
|
>= 2 cm |
<= 10 mm |
> 8 |
low |
|
>= 2 cm |
> 10 mm |
> 8 |
high |
This can be modeled as a risk score:
|
Parameter |
Finding |
Points |
|
tumor size |
< 2 cm |
0 |
|
|
>= 2 cm |
1 |
|
depth of invasion |
<= 10 mm |
0 |
|
|
> 10 mm |
1 |
|
histologic grade |
<= 8 |
0 |
|
|
> 8 |
2 |
total score =
= SUM(points for all 3 factors)
Interpretation:
• minimum score: 0
• maximum score: 4
|
Total Score |
Risk Group |
Estimated 5-Year Relapse Free Survival |
|
0 or 1 |
minimal |
100% |
|
2 or 3 |
low |
92% |
|
4 |
high |
45% |
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
ICD-10: ,
