Klein et al identified prognostic factors for patients with the Dandy-Walker malformation. These can help distinguish a patient with a relatively normal outcome from a patient with a poor prognosis. The authors are from Hopital Necker Enfants-Malades in Paris.


Patient selection: One who meets all of the criteria for the Dandy-Walker malformation (see previous section)


A patient with all of the following should have a normal outcome:

(1) normal karyotype

(2) minimal abnormality of the vermis, with partial agenesis

(3) rest of brain normal, without malformation


A patient with any of the following may have a poor outcome, with mental retardation and neurological impairment:

(1 abnormal karyotype

(2) severely dysplastic and malformed vermis

(3) severe brain malformations in the supratentorium, typically in the midline


To read more or access our algorithms and calculators, please log in or register.