Hui et al identified prognostic factors for patients with mantle cell lymphoma. This can help identify patients who may benefit from more aggressive management. The authors are from the University of Alberta in Edmonton, Alberta, Canada.
Parameters:
(1) International Prognostic Index (IPI)
(2) immunohistochemical staining with cdc2
(3) immunohistochemical staining with Ki67
|
Parameter |
Finding |
Points |
Median Survival |
|
IPI |
0 or 1 |
0 |
63 months |
|
|
2, 3, 4 or 5 |
1 |
35 months |
|
cdc2 staining |
<= 25% |
0 |
46 months |
|
|
> 25% |
1 |
11 months |
|
Ki67 staining |
<= 50% |
0 |
46 months |
|
|
>50% |
1 |
14 months |
where:
• Only 7 (23%) of the patients in the study had an IPI of 0 or 1.
In the implementation I used this data to generate a rough prognostic score from this data as follows:
total score for unfavorable factors =
= SUM(points for all 3 parameters)
Interpretation:
• minimum number of unfavorable findings: 0
• maximum number of unfavorable findings:3
|
Number of Unfavorable Factors |
Prognosis |
Estimated Median Survival |
|
0 |
good |
63 months |
|
1 |
fair |
35 months |
|
2-3 |
poor |
11 months |
Specialty: Hematology Oncology
