Geer and Brennan identified prognostic factors in 799 patients with pancreatic adenocarcinoma. The authors are from Memorial-Sloan Kettering Cancer Center in New York City.
Features of surgical resections:
(1) 18% of patients had curative resection
(2) 30 day operative mortality was 3.4%
(3) 5 year survival in patients who did not have resection was 0%
(4) 5 year survival in patients who had complete resection was 24%
Predictors of poor prognosis in univariate and multivariate analysis:
(1) metastasis to lymph nodes
(2) poor histologic tumor differentiation
(3) tumor size > 2.5 cm.
Parameter
Hazard Ratio
95% CI
p value
metastasis to lymph nodes
1.78
1.17 – 2.72
0.0073
tumor size > 2.5 cm
2.77
1.50 – 5.13
0.0011
poor histologic differentiation
1.82
1.19 – 2.79
0.0062
from Table II, page 71
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