Types of liposarcoma evaluated:
(1) myxoid
(2) round cell (round cells comprise > 5% of cellularity)
(3) pleomorphic
Parameters affecting disease specific survival:
(1) presentation (initial vs recurrent)
(2) tumor diameter in cm
(3) histologic grade
(4) surgical margins at resection
|
Parameter
|
Finding
|
Points
|
|
presentation
|
initial
|
0
|
|
|
recurrence
|
1
|
|
tumor diameter
|
<= 10 cm
|
0
|
|
|
> 10 cm
|
1
|
|
histologic grade
|
Grade I
|
0
|
|
|
Grade II or III
|
1
|
|
surgical margins
|
negative
|
0
|
|
|
positive
|
1
|
where:
• Location in an extremity and the use of radiation therapy impact local control and therefore likelihood of recurrent disease (local recurrence free survival).
• I would assume that tumor diameter and surgical margins refer to the initial resection.
total number of prognostic factors affecting disease specific survival =
= SUM(points for all of the parameters)
Interpretation:
• minimum number of poor prognostic factors: 0
• maximum number of poor prognostic factors: 4
Additional factors that impact metastases and post-metastases survival:
(1) histologic grade (metastases more likely with Grade II or III)
(2) histologic type (myxoid better than round cell or pleomorphic)
(3) extrapulmonary metastases
