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Prognostic Factors of Donato et al for a Patient with Glioblastoma Multiforme

Description

Donato et al evaluated patients treated for glioblastoma multiforme. A number of factors can help to identify patients with a worse prognosis. The authors are from University of Rome La Sapienza, IRCCS Neuromed (Pozzilli).


 

Patient selection: glioblastoma multiforme treated with surgery, radiation and temozolomide

 

Outcome: overall survival

 

Parameters:

(1) age in years

(2) postoperative Karnofsky performance score (KPS)

(3) tumor resection

(4) tumor diameter in cm

(5) Ki-67 proliferation index

 

Parameter

Finding

Points

age in years

< 60 years of age

0

 

>= 60 years of age

1

postoperative KPS

>= 80

0

 

<= 70

1

tumor resection

complete

0

 

incomplete

1

tumor diameter

<= 4 cm

0

 

> 4 cm

1

Ki-67 index

<= 15%

0

 

> 15%

1

 

total number of poor prognostic factors =

= SUM(points for all 5 parameters)

 

Interpretation:

• minimum number: 0

• maximum number: 5

• The outcome is worse as the number of poor prognostic factors increase.

 


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