de Jong et al evaluated prognostic factors for patients with intrahepatic cholangiocarcinoma. These can help to identify patients who may benefit from more aggressive management. The authors are from multiple hospitals in North America and Europe.
Parameters:
(1) number of tumors
(2) vascular invasion
(3) tumor at the surgical margin
(4) lymph node metastases
(5) invasion into adjacent organs
The best prognosis was a single tumor, total excised, without vascular invasion and without lymph node metastases (no risk factors).
The worst prognosis was a tumor with metastases to lymph nodes and direct extension into adjacent organs.
In general, a patient with lymph node metastases did worse than a patient without lymph node metastases.
In a patient without lymph node metastases, the number of of the first 2 risk factors (number of tumors, vascular invasion) present could be used to separate patients into different risk groups.
Lymph Node Status
Number of Risk Factors
3 Year Survival
N0
0
65%
N0
1
48%
N1
0
44%
N1
1
29%
N0
2
28%
N1
2
17%
from Figure 2, page 3143
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