Prognostic Factors of D'Antiga et al for a Patient with a Hepatoblastoma

Description

D'Antiga et al identified prognostic factors for patients with hepatoblastoma. These can help identify a patient with unresectable tumor who may benefit from liver transplantation. The authors are from the University of Padova and Istituto Oncologico Veneto IRCSS in Italy.

Patient selection: no distant metastases

Parameters for evaluation at presentation:

(1) age of the patient

(2) PRETEXT group

(3) number of tumor foci

(4) vascular involvement (portal vein, hepatic vein, inferior vena cava)

(5) serum alpha-fetoprotein (AFP)

Parameter	Finding	Points
age	younger (median 0.7 years)	0
	older (median 4.2 years)	1
PRETEXT group	1 or 2	0
	3 or 4	1
number of tumor foci	1	0
	multifocal	1
vascular involvement	absent	0
	present	1
serum AFP	>= 100 ng/mL	0
	< 100 ng/mL	1

number of poor prognostic factors =

= SUM(points for all 5 parameters)

Interpretation:

• minimum number of poor prognostic factors: 0

• maximum number: 5

• The higher the score the worse the prognosis and the more likely that the patient will benefit from liver transplantation.

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Description

Specialty

ICD-10