Prognostic Factors of Cotterill et al for a Patient with Ewing’s Sarcoma of Bone

Description

Cotterill et al identified prognostic factors for a patient with Ewing’s sarcoma of bone. These can help to identify a patient who may benefit from more aggressive management or a novel therapy. The authors are from the University of Newcastle upon Tyne and the study was based on data from the European Intergoup Cooperative Ewing’s Sarcoma Study Group.

Patient selection: Ewing’s sarcoma of bone

Favorable prognostic factors:

(1) absence of metastases at diagnosis

(2) no relapse after treatment

Unfavorable factors:

(1) metastases to bone at diagnosis

(2) relapse within 2 years of diagnosis

For patients without metastases at diagnosis unfavorable findings were:

(3) age >= 15 years

(4) primary in the axial skeleton

Patients treated after 1985 had better survival than those treated before.

About 1% of patients (9 out of 975) developed a second malignancy.

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Prognostic Factors of Cotterill et al for a Patient with Ewing’s Sarcoma of Bone

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