Castillo et al identified prognostic factors for a patient with Bing-Neel syndrome associated with Waldenstrom macroglobulinemia. The authors are from multiple institutions in the United States and Europe.


Patient selection: Bing-Neel syndrome (BNS)


Factors associated with a worse prognosis:

(1) age > 65 years

(2) platelet count < 100,000 per µL

(3) therapy for Waldenstrom's macroglobulinemia prior to diagnosis of BNS


Factors associated with a better prognosis:

(1) therapy with rituximab


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