Bjorneklett et al evaluated patients with anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis. These can help to identify a patient who may require more aggressive management. The authors are from University of Bergen, Haukeland University Hospial and Western Norway University of Applied Sciences.
Patient: ANCA-associated glomerulonephritis in ANCA-associated vasculitis (AAV)
(1) pauci-immune
(2) positive ANCA
(3) sclerosing glomerulonephritis
Outcome: end-stage renal disease (ESRD)
Prognostic factors:
(1) percentage of normal glomeruli
(2) initial eGFR in mL per min per 1.73 square meters
Parameter
Finding
5-Year ESRD
normal glomeruli
> 10%
83%
<= 10%
39%
eGFR
> 15 mL/min/1.73 sq m
77%
<= 15 mL/min/1.73 sq m
15%
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