Prognostic Factors of Benner et al for a Patient with Transformed Mycosis Fungoides

Description

Benner et al reported prognostic factors for a patient with mycosis fungoides following large cell transformation (LCT). These can help to identify a patient who may or may not require more aggressive management. The authors are from Leiden University Medical Center in the Netherlands.

Patient selection: large cell transformation of mycosis fungoides

Prognostic factors:

(1) CD30 positivity on immunostaining

(2) extent of skin lesions

(3) extracutaneous lesions

(4) follicultrophic mycosis fungoides

Parameters	Findings	Points
CD30 immunostaining	positive	0
	negative	1
extent of skin lesions	solitary or localized	0
	generalized	1
extracutaneous lesions	absent	0
	present	1
folliculotrophic pattern	absent	0
	present	1

where:

• Generalized = multiple skin lesions in more than 1 skin location.

• Age >= 60 years was a poor prognostic feature for a patient with skin lesions only.

total score =

= SUM(points for all 4 parameters)

Interpretation:

• minimum score: 0

• maximum score: 4

• The higher the score the worse the prognosis for the patient.

Total Score	Risk Group	Disease Specific Surrvival (DSS) at 5 Years
0 or 1	low	65%
2 to 4	high	15%

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Description

Specialty

ICD-10