Prognostic Factors of Bellmunt et al for a Patient with Metastatic Transitional Cell Carcinoma That Is Refractory to Platinum-Based Chemotherapy

Description

Bellmunt et al identified factors associated with a worse prognsosis for a patient with metastatic transitional cell carcinoma that is resistant to platinum-based chemotherapy. These can help to identify patients who may benefit from more aggressive or a novel therapy. The authors are from multiple institutions in Europe and North America.

Patient selection: metastatic transitional cell carcinoma of the urothelial tract

Parameters:

(1) ECOG performance status

(2) hemoglobin in g/dL

(3) liver metastases

Parameter	Finding	Points
ECOG performance status	0	0
	>= 1	1
hemoglobin in g/dL	>= 10 g/dL	0
	< 10 g/dL	1
liver metastases	absent	0
	present	1

number of adverse prognostic factors =

= SUM(points for all 3 parameters)

Interpretation:

• minimum number: 0

• maximum number: 3

• The greater the number the worse the prognosis.

Number of Factors	Median Overall Survival
0	14.2 months
1	7.3 months
2	3.8 months
3	1.7 months

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Description

Specialty

ICD-10