A variety of prognostic factors are associated with outcome in patients with osteosarcoma.
Parameter |
Significance |
T classification (TNM) |
T1 (confined within cortex) better than T2 (extends beyond the cortex) |
histologic grade |
well (G1) and moderately differentiated (G2) better than poorly (G3) or undifferentiated (G4) |
location |
resectable better than unresectable |
size of primary tumor |
<= 15 cm better than > 15 cm |
serum levels alkaline phosphatase |
normal serum levels better than elevated levels |
serum levels of LDH |
normal serum levels better than elevated levels |
extent |
localized better than metastatic |
metatastic sites |
solitary lung metastasis better than multiple |
|
bone or liver metastases much worse than lung |
histologic response to preoperative chemotherapy |
> 90% necrosis (good response) is better than <= 90% |
Specialty: Hematology Oncology, Surgery, general, Surgery, orthopedic
ICD-10: ,