Prognostic Factors in Neuroblastoma

A variety of clinical and laboratory findings correlate with clinical outcome in patients with neuroblastoma.

Parameter	Favorable	Unfavorable
age in years	< 2	>= 2
histologic type according to Shimada et al	favorable	unfavorable
clinical stage of Evans et al	I, II, IVS	III, IV
lymphocytic infiltration	present	absent
cytogenetics	hyperdiploid	diploid
urinary VMA/HVA ratio	>= 1	< 1
NSE	normal (<= 100 ng/mL)	increased (> 100 ng/mL)
serum LDH	low	increased
serum ferritin	low (<= 150 ng/mL)	increased (> 150 ng/mL)
N-myc amplification	absent	present
TRK gene expression (nerve growth factor receptor, NGFR)	high	low
ganglioside Gt1b	present	absent
bcl-2 expression	absent	present
P-glycoprotein (multi-drug resistance protein)	absent	present

where:

• the upper limit of serum ferritin in a child or young adolescent is about 140-150 ng/mL; the upper limit varies at other ages

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