With aggressive therapy many patients with Burkitt's lymphoma may have good response and cure. However, the presence of certain findings may be associated with a poor outcome. A patient with one or more risk factors for poor outcome may benefit from more aggressive therapy.
Poor prognostic factors in Burkitt's lymphoma:
(1) involvement of the central nervous system
(2) involvement of the bone marrow
(3) an elevated pretreatment serum LDH (> 500 IU/L, with upper limit of normal 200 IU/L)
(4) bulky tumor (unresected tumor > 10 cm in maximal diameter)
An elevated serum uric acid (> 9 mg/dL) has also been associated with a worse prognosis.
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