Lewis et al studied prognostic factors for synovial sarcomas localized to the extremity. The authors are from the Memorial Sloan Kettering Cancer Center in New York.
Criteria for localized primary tumor:
(1) previously untreated or the biopsy was done at the time of presentation
(2) no evidence of metastasis
Parameters found by multivariate analysis to be independent adverse predictors:
(1) tumor size
(2) tumor invasion
Criteria for tumor invasion:
(1) bone invasion: invasion of tumor through the periosteum and breaching the cortex
(2) neurovascular invasion: invasion into the perineurium of a nerve or through the intima of a large vein or artery
|
Risk Factor |
Finding |
Points |
|
tumor size |
>= 5 cm |
1 |
|
|
< 5 cm |
0 |
|
bone or neurovascular invasion |
present |
1 |
|
|
absent |
0 |
number of risk factors =
= (points for tumor size) + (points for invasion)
Interpretation:
• minimum number: 0
• maximum number: 2
|
Number of Risk Factors |
Free of Distant Recurrence at 5 Years |
5 Year Survival |
|
0 |
75% |
86% |
|
1 |
47% |
66% |
|
2 |
26% |
40% |
from page 2090
|
Risk Factor |
Relative Risk for Distant Recurrence |
Relative Risk for Mortality |
|
tumor size >= 5 cm |
2.7 (95% 1.5 to 5.2) |
2.3 (95% 1.4 to 6.3) |
|
bone or neurovascular invasion |
2.3 (95% 1.0 to 5.3) |
2.7 (95% 1.0 to 6.5) |
Specialty: Hematology Oncology, Surgery, general, Surgery, orthopedic
ICD-10: ,
