Synovial sarcoma (SS) is an uncommon soft tissue sarcoma that often affects young adults. A number of features may affect overall survival.
Synovial sarcoma is associated with the t(X;18)(p11.2;q11.2) translocation, which results in a SS18-SSX fusion gene.
Variant fusion genes: SS18-SSX1, SS18-SSX2 and SS18-SSX4
Factors associated with better overall survival:
(1) younger age (age < 33 years in Ren et al; <35 years in Charbonneau et al)
(2) tumor size < 5 cm
(3) UICC stage 1 or 2
(4) FNCLCC Grade 2
(5) biphasic histology
(6) SS18-SSX2 fusion gene by PCR (versus SS18-SSX1)
(7) higher expression of FGFR3 (fibroblast growth factor receptor)
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Specialty: Hematology Oncology, Surgery, general, Surgery, orthopedic
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