Dighiero G and Hamblin listed a prognostic classification for patients with chronic lymphocytic leukemia (CLL). This is based on reports by Oscier et al and Vasconcelos et al. The authors are from Institut Pasteur de Montevideo in Uruguay and the University of Southampton.
Parameters:
(1) 17p deletion (affecting p53)
(2) IGVH gene mutation
(3) Binet stage
del 17p
IGVH mutation
Binet Stage
Survival in months (median)
Management
absent
present
A
> 144
wait and watch
absent
present
B or C
120
wait and watch, or early treatment
absent
absent
A
97
wait and watch, or early treatment
absent
absent
B or C
78
early treatment
present
NA
NA
36
early treatment, consider unconventional treatment
where:
• The "watch and wait" approaches to action if there is disease progression.
• Enrollment in a clinical trial should be considered if treatment is planned.
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