Prognostic Classes of Sarkaria et al for High Grade Malignant Gliomas

Description

Sarkaria et al identified prognostic classes of high grade malignant gliomas using RTOG (Radiation Therapy Oncology Group) analysis. These can help compare outcomes following therapeutic interventions. The authors are from the University of Wisconsin, Harvard University and the University of Florida at Gainesville.

Selection criteria included age > 18 years.

Parameter:

(1) type (anaplastic astrocytoma vs glioblastoma multiforme)

(2) age of the patient

(3) mental status

(4) Karnofsky performance scale (KPS)

(5) duration of symptoms before diagnosis

(6) functional status

(7) surgery (partial or total resection vs biopsy)

Anaplastic Astrocytoma

Parameter	Class 1	Class 2	Class 3
age in years	< 50 years	>= 50 years	< 50 years
mental status	normal		abnormal
KPS		>= 70
duration		> 3 months
functional status
surgery

Parameter	Class 4	Class 5	Class 6
age in years	>= 50 years	>= 50 years	>= 50 years
mental status		normal	abnormal
KPS	>= 70	< 70	< 70
duration	<= 3 months
functional status
surgery

Glioblastoma Multiforme

Parameter	Class 3	Class 4a	Class 4b
age in years	< 50 years	< 50 years	>= 50
mental status
KPS	>= 90	< 90	>= 70
duration
functional status			working
surgery			resection

Parameter	Class 5a	Class 5b	Class 5c
age in years	>= 50	>= 50	>= 50
mental status			normal
KPS	>= 70	>= 70	< 70
duration
functional status	not working
surgery	resection	biopsy

Parameter	Class 6
age in years	>= 50 years
mental status	abnormal
KPS	< 70
duration
functional status
surgery

Patients were treated with surgery, external beam radiation and linac-based radiosurgery.

Prognostic classes 1, 2 and 3 had a relatively favorable outcome with survival at 2 years from 75-81% (75% at 3 years for 1 and 2, 45% at 3 years for group 3).

Prognostic classes 4, 5 and 6 had a relatively unfavorable outcome with survival at 2 years from 21-34% (< 10% at 3 years).

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Prognostic Classes of Sarkaria et al for High Grade Malignant Gliomas

Description

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