Pretransplantation Assessment of Mortality (PAM) Score for a Patient Undergoing an Allogeneic Stem Cell Transplantation

CML in chronic phase, refractory anemia, aplastic anemia, Blackfan-Diamond Syndrome

low risk

CML in accelerated phase, CML in chronic phase after a blastic phase, acute leukemia in remission, malignant lymphoma in remission, refractory anemia with excess blasts, CLL, PNH

intermediate risk

CML in blastic phase, juvenile CML, acute leukemia, active malignant lymphoma, refractory anemia with excess blasts in transformation, myeloma, solid tumors, nonhematologic disorder

high risk

age of the patient in years

< 50

1

50 to 60

3

> 60

5

donor type

related, matched

1

unrelated

3

related, mismatch

4

disease risk

low

1

intermediate

8

high

12

conditioning regimen

nonmyeloablative

1

non total body irradiation (TBI)

4

TBI <= 12 Gy

8

TBI > 12 Gy

9

serum creatinine

<= 1.2 mg/dL (<= 106 µmol/L)

1

> 1.2 mg/dL (> 106 µmol/L)

8

serum ALT

<= 49 IU/L

1

> 49 IU/L

2

FEV1

> 80%

1

70 - 80%

3

< 70%

6

carbon monoxide diffusing capacity

>= 70%

1

< 70%

4

Total Score

Mortality Risk

<= 16

< 25%

17 to 23

25 - 50%

24 to 30

50 - 75%

>= 31

> 75%