Preoperative Prognostic Factors of Liang et al for a Patient with Glioblastoma Multiforme

Description

Liang et al identified a number of prognostic factors for a patient undergoing surgery for glioblastoma multiforme. These can help to identify a patient who may benefit from more aggressive management. The authors are from National Taiwan University.

Patient selection: glioblastoma, prior to tumor resection

Outcome: overall survival

Preoperative parameters:

(1) Karnofsky Performance Status (KPS)

(2) abnormal neurologic status

(3) age

(4) ability to work

Age in Years	KPS	Ability to Work	Overall Survival
< 50	>= 90	NA	29.8 months
< 50	< 90	NA	18 months
>= 50	>= 70	able	18 months
>= 50	>= 70	unable	11.1 months
>= 50	< 70	NA	11.1 months

KPS	Neurologic Status	Overall Survival
>= 90	normal	26.1 months
>= 90	abnormal	14.9 months
80	normal	20.6 months
80	abnormal	14.1 months
<= 70	normal	11.5 months
<= 70	abnormal	7 months

Signs of increased intracranial pressure (IICP):

(1) headache

(2) vomiting

(3) drowsiness

(4) ocular palsy

Other neurological signs:

(1) aphasia

(2) amnesia

(3) apraxia

(4) disorientation

(5) personality change

(6) slow response

(7) extremity weakness

(8) facial palsy

(9) dysarthria

(10) objective sensory impairment

(11) visual field defect

(12) visual accuracy defect

(13) gait disturbance not related to muscle weakness

(14) cerebellar signs

Number IICP Signs	Number Other Signs	Total	Median Overall Survival
>= 1	>= 1	>= 3	9.6 months
<= 1	<= 1	<= 2	18.7 months

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Preoperative Prognostic Factors of Liang et al for a Patient with Glioblastoma Multiforme

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