A woman with Fanconi anemia may experience premature menopause.

Mechanism: premature ovarian insufficiency with dysfunction and/or depletion of ovarian follicles


Clinical features:

(1) amenorrhea in a woman less than 40 years of age for > 4 months

(2) history of subfertility or infertility

(3) elevated serum FSH

(4) history of Fanconi anemia

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