Zubkov et al identified factors associated with a poor outcome for a patient with intracerebral hemorrhage (ICH) associated with warfarin therapy. These factors can help to identify a patient who may benefit from more aggressive management. The authors are from the Mayo Clinic in Rochester.


Outcomes measured:

(1) 7 day mortality rate

(2) functional outcome at hospital discharge

(3) long-term outcome (30 days or more)


Parameters affecting long-term outcome:

(1) volume of the intracerebral hemorrhage

(2) level of consciousness at presentation as measured with the Glasgow Coma Score



Better Outcome

Worse Outcome

volume of the hemorrhage

small (mean 6 mL)

large (mean 18 mL)

Glasgow Coma Score

higher (mean 14)




• The data makes selection of cutoffs a bit challenging. For the implementation cutoffs for worse prognosis are > 10 mL ICH and < 13 GCS.


Factors not identified as predictors in multivariate analysis of long-term outcome:

(1) glucose level

(2) magnitude of the INR on admission

(3) rapidity of INR correction


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