Truong et al identified predictive factors for successful peripheral stem cell mobilization and collection in pediatric patients. These can help to identify a patient who may benefit from more aggressive management. The authors are from Alberta Children's Hospital and University of Calgary.
Patient selection: pediatric patient requiring autologous stem cell transplant or healthy sibling of affected patient
Method of stem cell collection: apheresis
Ideal stem cell collection: >= 5 * 10^6 CD34+ cells per kg per intended transplant
Predictors of a good stem cell collection from peripheral blood:
(1) brain tumor (successful in 85% vs 95+% with other; OR 0.07
If a patient is a risk of an unsuccessful harvest, then multiple collections may be required and/or the patient should receive a stem cell mobilizing agent.
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