Tellier et al identified a number of factors associated with poor prognosis in a patient with the CHARGE syndrome. The authors are from multiple hospitals in France.


Patient selection: CHARGE syndrome


Risk factors for poor survival:

(1) male gender

(2) presence of a tracheo-esophageal fistula

(3) presence of a midline CNS malformation

(4) bilateral choanal atresia


Midline CNS malformations include:

(1) agenesis of the corpus callosum

(2) arhinencephaly

(3) septal agenesis

(4) meningoencephalocele

(5) partial agenesis of the vermis


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