Sofou et identified factors associated with poor survival for a patient with Leigh Syndrome. The authors are from University of Gothenburg and The Queen Silvia's Children Hospital in Gothenburg, Sweden.

Patient selection: Leigh syndrome


Predictors of acute exacerbation and/or relapses:

(1) pathological signs at birth

(2) history of epileptic seizures


Predictors of poor survival:

(1) disease onset before 6 months of age

(2) failure to thrive

(3) brainstem lesion on MRI

(4) intensive care unit admission

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