Sofou et identified factors associated with poor survival for a patient with Leigh Syndrome. The authors are from University of Gothenburg and The Queen Silvia's Children Hospital in Gothenburg, Sweden.
Patient selection: Leigh syndrome
Predictors of acute exacerbation and/or relapses:
(1) pathological signs at birth
(2) history of epileptic seizures
Predictors of poor survival:
(1) disease onset before 6 months of age
(2) failure to thrive
(3) brainstem lesion on MRI
(4) intensive care unit admission
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