Simonini et al identified factors predictive of remission of childhood uveitis after discontinuation of systemic therapy. This can help to identify a patient who may benefit from more aggressive management. The authors are from the University of Florence, Ospedale Pediatrico Bambino Gesu in Rome and the University of Trieste.

Patient selection: childhood (disease onset at age <= 16 years) autoimmune uveitis, after discontinuation of systemic therapy with disease inactivity


Predictors of remission and delayed relapse:

(1) idiopathic uveitis (versus juvenile idiopathic arthritis, JIA)

(2) uveitis inactivity achieved within 6 months of starting systemic therapy

(3) systemic therapy with anti-TNF alpha targeted agent


The chances of a better outcome are best when all 3 predictors are present and worse when none are seen.

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