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Predictors of Simonini et al for Maintaining Remission of Systemic Therapy for Childhood Autoimmune Chronic Uveitis

Description

Simonini et al identified factors predictive of remission of childhood uveitis after discontinuation of systemic therapy. This can help to identify a patient who may benefit from more aggressive management. The authors are from the University of Florence, Ospedale Pediatrico Bambino Gesu in Rome and the University of Trieste.


Patient selection: childhood (disease onset at age <= 16 years) autoimmune uveitis, after discontinuation of systemic therapy with disease inactivity

 

Predictors of remission and delayed relapse:

(1) idiopathic uveitis (versus juvenile idiopathic arthritis, JIA)

(2) uveitis inactivity achieved within 6 months of starting systemic therapy

(3) systemic therapy with anti-TNF alpha targeted agent

 

The chances of a better outcome are best when all 3 predictors are present and worse when none are seen.


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